BORN: 19 october, 1937 in Baku, USSR
Director, Engelhardt Institute of Molecular Biology, Russian Acad. Sci., Moscow 119991 , Vavilov str. 32, RUSSIA
Phone: 7095/1350559; Fax: 1351405; E-mail: email@example.com
Professor & Chairman, Department of Molecular Biophysics at the Faculty of Physico-Chemical Biology, Moscow Physico-Technical Institute, RUSSIA
1962 Graduated from Institute of Fine Chemical Technology (Moscow)
1967 Visiting Scientist, Institute of Organic Chemistry and Biochemistry, Czech, Acad. Sci. (Prague, Czechoslovakia)
1971 Visiting Scientist, MRC Laboratory of Molecular Biology (Cambridge, England)
1975-76 Visiting Scientist, California Institute of Technology (Pasadena) and Harvard University (Boston)
1965 Candidate of Chemical Sciences
1973 Doctor of Chemical Sciences
1981 Corresponding member of the USSR Academy of Sciences
1987 Full member of the USSR Academy
1990 Member of the Academia Europaea
1998 Member of the Deutsche Akademie der Naturforscher Leopoldina
2000 Member of Honor of Fundacion Valenciana de Estudios Avanzados (Spain)
1969 USSR State Prize for Science and Technology
1978 FEBS Anniversary Prize
1982 FEBS Lecture Tour in France and Switzerland
1989 Gregor-Mendel-Medaille of the Deutsche Akademie der Naturforscher Leopoldina
1999 Gold Engelhardt Medal of Russian Academy of Sciences
1999 State Order of Honor of the Russian Federation
1961 Senior Technician, IMB, Moscow
1962 Junior Researcher, IMB, Moscow
1969 Senior Scientist, IMB, Moscow
1973 Chief of Laboratory, IMB, Moscow
1984 Deputy Director, IMB, Moscow
1984 - present Director, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
1988-1990 Academician-Secretary of the USSR Academy of Sciences
1990-present Chairman of the Department of Molecular Biophysics at the Faculty of Physico-Chemical Biology in Moscow Physico-Technical Institute
1994-2001 Senior Scientist and Director, Biochip Technology Center, Argonne National Laboratory, 9700 South Cass Ave., Bldg. 202-A253, Argonne, IL 60439-4833, U.S.A.
OTHER PROFESSIONAL ACTIVITIES:
Member, Scientific Coordination Committee of the UNESCO Program on Human Genome, since 1991.
Vice President, Human Genome Organization (HUGO), 1989-1994.
Vice-Chairman, Russian Human Genome Project, 1988 - present.
Invited Lecturer, at more than 40 International conferences. Chairman of the Organizing Committee of over 15 International conferences organized in FSU countries and Russia.
Editorial Board Member -J. DNA Sequencing. Advisory Board Member -Gene.
Supervisor, for 35 Candidate of Science theses and Consultant for 3 Doctor of Science theses
MAJOR SCIENTIFIC RESULTS:
Participation in determination of nucleotide sequence of yeast valine tRNA.
Identification of the regions in valine tRNA that are important for recognition of valyl-tRNA synthetase and interaction with ribosomal subunits by the developed method of dissected tRNA molecules.
Demonstration of restoration of functional activities of tRNA upon reassembly of the molecules from several fragments.
Use of cationic detergent for tRNA crystallization.
Development of a method to test DNA double helix grooves andsingle-stranded DNA regions by the use of modification with dimethyl sulphate and its application for chromatin and specific and non-specific complexes of lac-repressor and RNA polymerase with DNA.
Suggestions for development of Maxam-Gilbert sequencing method.
Development of new techniques for identification of proteins on specific DNA sequencing, for sequencing the linear arrangement of proteins alongDNA and for location of contacts in proteins and DNA in their complexes.
Determination of the primary organization (the linear arrangement of proteins along DNA) of nucleosomes, RNA-polymerase-promoter complexes, and some chromatin regions.
Development of a new method for mapping proteins along genomic DNA by DNA-protein crosslinking.
Development of a new technique for sequencing nucleic acids by their hybridization with oligonucleotides microchips (SHOM).
Development of the technologies and methods for manufacturing and use of biological microchips containing immobilized oligonucleotides, DNA, and proteins.
Application of biochips for diagnostics of genetic diseases, gene polymorphism studies, microbial identification, gene expression analysis, forensic studies, comparative sequence analysis, etc.