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Andrei D. Mirzabekov

BORN:   19 october, 1937 in Baku, USSR

CURRENT POSITIONS:

Director, Engelhardt Institute of  Molecular  Biology, Russian Acad. Sci., Moscow 119991 , Vavilov str. 32, RUSSIA

Phone: 7095/1350559; Fax: 1351405; E-mail: amir@eimb.ru

Professor & Chairman, Department of Molecular Biophysics at the Faculty of Physico-Chemical Biology, Moscow Physico-Technical Institute, RUSSIA

EDUCATION:

1962   Graduated from Institute of Fine Chemical Technology (Moscow)

1967   Visiting Scientist, Institute of Organic Chemistry and Biochemistry, Czech, Acad. Sci. (Prague, Czechoslovakia)

1971   Visiting Scientist, MRC Laboratory of Molecular Biology (Cambridge, England)

1975-76   Visiting Scientist, California Institute of Technology (Pasadena) and Harvard University (Boston)

ACADEMIC RECORD:

1965   Candidate of Chemical Sciences

1973   Doctor of Chemical Sciences

1981   Corresponding member of the USSR Academy of Sciences

1987   Full member of the USSR Academy

1990   Member of the Academia Europaea

1998   Member of the Deutsche Akademie der Naturforscher Leopoldina

2000   Member of Honor of Fundacion Valenciana de Estudios Avanzados (Spain)

HONOURS:

1969   USSR State Prize for Science and Technology

1978   FEBS Anniversary Prize

1982   FEBS Lecture Tour in France and Switzerland

1989  Gregor-Mendel-Medaille of the Deutsche Akademie der Naturforscher Leopoldina

1999   Gold Engelhardt Medal of Russian Academy of Sciences

1999   State Order of Honor of the Russian Federation

EMPLOYMENT HISTORY:

1961   Senior Technician, IMB, Moscow

1962   Junior Researcher, IMB, Moscow

1969   Senior Scientist, IMB, Moscow

1973   Chief of Laboratory, IMB, Moscow

1984   Deputy Director, IMB, Moscow

1984 - present    Director, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

1988-1990  Academician-Secretary of the USSR Academy of Sciences

1990-present  Chairman of the Department of Molecular Biophysics at the Faculty of Physico-Chemical Biology in Moscow Physico-Technical Institute

1994-2001  Senior Scientist and Director, Biochip Technology Center, Argonne National Laboratory, 9700 South Cass Ave., Bldg. 202-A253, Argonne, IL 60439-4833, U.S.A.

OTHER PROFESSIONAL ACTIVITIES:

Member, Scientific Coordination Committee of the UNESCO Program on Human Genome, since 1991.

Vice President, Human Genome Organization (HUGO), 1989-1994.

Vice-Chairman, Russian Human Genome Project, 1988 - present.

Invited Lecturer, at more than 40 International conferences. Chairman of the Organizing Committee of over 15 International conferences organized in FSU countries and Russia.

Editorial Board Member -J. DNA Sequencing. Advisory Board Member -Gene.

Supervisor, for 35 Candidate of Science theses and Consultant for 3 Doctor of Science theses

MAJOR SCIENTIFIC RESULTS:

Participation in determination of nucleotide sequence of yeast valine tRNA.

Identification of the regions in valine tRNA that are important for recognition of valyl-tRNA synthetase and interaction with ribosomal subunits by the developed method of dissected tRNA molecules.

Demonstration of restoration of functional activities of tRNA upon reassembly of the molecules from several fragments.

Use of cationic detergent for tRNA crystallization.

Development of a method to test DNA double helix grooves andsingle-stranded DNA regions by the use of modification with dimethyl sulphate and its application for chromatin and specific and non-specific complexes of lac-repressor and RNA polymerase with DNA.

Suggestions for development of Maxam-Gilbert sequencing method.

Development of new techniques for identification of proteins on specific DNA sequencing, for sequencing the linear arrangement of proteins alongDNA and for location of contacts in proteins and DNA in their complexes.

Determination of the primary organization (the linear arrangement of   proteins along DNA) of nucleosomes, RNA-polymerase-promoter complexes, and some chromatin regions.

Development of a new method for mapping proteins along genomic DNA by DNA-protein crosslinking.

Development of a new technique for sequencing nucleic acids by their hybridization with oligonucleotides microchips (SHOM).

Development of the technologies and methods for manufacturing and use of biological microchips containing immobilized oligonucleotides, DNA, and proteins.

Application of biochips for diagnostics of genetic diseases, gene polymorphism studies, microbial identification, gene expression analysis, forensic studies, comparative sequence analysis, etc.